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Pharmacology: DIOSPER is a phlebotonic drug and a vascular protecting agent. Its efficacy is accounted for its specific action on the principal elements of venous disease.
Venous tonic activity: DIOSPER is a phlebotonic. It reinforces venous tone by prolonging the activity of parietal noradrenaline. Thus, it decreases venous capacitance, venous distensibility and venous emptying time.
Microcirculatory activity: DIOSPER protects microcirculation by fighting the microcirculation-damaging process. It combats venous inflammation by decreasing leukocyte activation and as a consequence, by inhibiting the release of inflammatory mediators, principally free radicals and prostaglandins. Thus, it normalizes capillary permeability and strengthens capillary resistance.
DIOSPER acts on the lymphatic system. It improves lymphatic drainage by increasing lymph flow and lymph oncotic pressure. This action on the lymphatic system associated with phlebotonic and vasculoprotective effect, explains the activity of DIOSPER on CVI-associated edema.
Pharmacokinetics: In man, following the administration of the substance containing 14C Diosmin: Excretion is mainly fecal, a mean of 14% of the dose administered is excreted in the urine.
Elimination half-life is 11 hours.
The drug is extensively metabolized as evidenced by the presence of various phenol acids in the urine.
