Dilatrend Overdosage

Symptoms and signs of overdose: In the event of overdosage, there may be severe hypotension, bradycardia, heart failure, cardiogenic shock and cardiac arrest. There may also be respiratory problems, bronchospasm, vomiting, disturbed consciousness and generalised seizures.
Treatment of overdose: The patients should be monitored for the above mentioned signs and symptoms and managed according to the best judgment of the treating physicians and according to standard practice for patients with β-blocker overdose (e.g. atropine, transvenous pacing, glucagon, phosphodiesterase inhibitor such as amrinone or milrinone, β sympathomimetics).
Important note: In cases of severe intoxication with shock, supportive treatment must be continued for a sufficiently long period, as a prolongation of elimination half-life and redistribution of carvedilol from deeper compartments are to be expected. The duration of the supportive/antidote therapy depends on the severity of the overdose. The supportive treatment should therefore be continued until the patient's condition has stabilised.