Digox Use In Pregnancy & Lactation

Pregnancy: The use of digoxin in pregnancy is not contraindicated, although the dosage may be less predictable in pregnant than in non-pregnant women, with some requiring and increased dosage of digoxin during pregnancy. As with all drugs, use should be considered only when the expected clinical benefit of treatment to the mother outweighs any possible risk to the developing fetus.
Despite extensive antenatal exposure to digitalis preparations, no significant adverse effects have been observed in the fetus or neonate when maternal serum digoxin concentrations are maintained within normal range. Although it has been speculated that a direct effect of digoxin on the myometrium may result in relative prematurity and low birthweight, a contributing role of the underlying cardiac disease cannot be excluded. Maternally administered digoxin has been successfully used to treat fetal tachycardia and congestive heart failure.
Adverse fetal effects have been reported in mothers with digitalis toxicity.
Lactation: Although digoxin is excreted in breast milk, the quantities are minute and breastfeeding is not contraindicated.