Difenax Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Diclofenac Na

Indications/Uses

Relief of pain & inflammation in musculoskeletal & joint disorders eg, RA, OA, & ankylosing spondylitis; peri-articular disorders eg, bursitis & tendinitis; soft-tissue disorders eg, sprains & strains; other painful conditions eg, renal colic, acute gout, dysmenorrhea, & post-op pain.

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Dosage/Direction for Use

1 tab bid-tid.

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Overdosage

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Administration

Should be taken with food: Take immediately after meals.

Contraindications

Hypersensitivity. Active gastric or intestinal ulcer, bleeding or perforation. Patients whom attacks of asthma, urticaria, or acute rhinitis are precipitated by ASA or other NSAIDs. Severe hepatic, renal or cardiac failure. Pregnancy (last trimester).

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Warnings

For additional cautionary notes to warn of the potential risk of using the medicine... Click to view Difenax detailed prescribing information

Special Precautions

Not to be given to patients w/ history of CVA, MI, CABG, uncontrolled HTN, CHF NYHA II-IV; history of peptic ulcers, asthma or bronchospasm, bleeding disorders & those receiving coumarin anticoagulants. Patients w/ cardiac decompensation, HTN & renal disease; suffering from severe hepatic or renal damage. Not to be used during pregnancy (1st & 2nd trimester) & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

GI discomfort, nausea, & diarrhea. Peptic ulceration & severe GI bleeding.

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Drug Interactions

Enhanced effects of oral anticoagulants. Increased plasma conc of lithium, MTX, & cardiac glycosides. Increased risk of nephrotoxicity w/ ACE inhibitors, ciclosporin, tacrolimus, or diuretics. Increased risk of hyperkalaemia w/ ACE inhibitors & some diuretics including K-sparing diuretics. Reduced antihypertensive effects of ACE inhibitors, β-blockers, & diuretics. Convulsions w/ quinolones. Increase effects of phenytoin & sulfonylureas. Increased risk of adverse effects w/ other NSAIDs including aspirin & misoprostol. Increased risk of GI bleeding & ulceration w/ corticosteroids, SSRIs, venlafaxine, antiplatelets, or pentoxifylline. Increased risk of haematotoxicity w/ zidovudine. May increase plasma conc w/ ritonavir. Alter efficacy of mifepristone.

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Storage

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Description

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Action

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MIMS Class

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

ATC Classification

M01AB05 - diclofenac ; Belongs to the class of acetic acid derivatives and related substances of non-steroidal antiinflammatory and antirheumatic products.

Regulatory Classification

Presentation/Packing

Form

Difenax EC tab 50 mg

Packing/Price

100's (P9.05/enteric-coated tab)

Difenax

diclofenac

Manufacturer:

GXI

Distributor:

Metro Drug