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Reports of acute toxicity and/or deaths following overdosage with glucocorticoids are rare. No antidote is available. Treatment is probably not indicated for reactions due to chronic poisoning, unless the patients have a condition that would render a patient unusually susceptible to ill effects from corticosteroids. In this case, symptomatic treatment should be instituted as necessary.
Anaphylactic and hypersensitivity reactions may be treated with adrenaline, positive pressure artificial respiration and aminophylline. The patient should be kept warm and quiet.
The biological half-life of Dexamethasone in plasma is about 190 minutes.
