Depotrust Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing Brand Resources

Concise Prescribing Info

Contents

Medroxyprogesterone acetate

Indications/Uses

Contraception & treatment of menorrhagia, secondary amenorrhea & mild to moderate endometriosis.

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Dosage/Direction for Use

IM Contraception & menorrhagia 150 mg/3 mL w/in the 1st 7 days of cycle or w/in 1st 4 wk after giving birth (delay until 6 wk after giving birth if breastfeeding). Secondary amenorrhea 5-10 mg daily for 5-10 days until 2 days before onset of menstruation. Mild to moderate endometriosis 50 mg wkly or 100 mg every 2 wk for at least 6 mth.

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Overdosage

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Contraindications

Undiagnosed vag bleeding, history or current high risk of arterial disease, hormone-dependent neoplasms, porphyria, after recent evacuation of hydatidiform mole. Hepatic impairment (especially if severe). Pregnancy.

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Special Precautions

Cardiac impairment, epilepsy, asthma, history of depression, DM, HTN, migraine, thromboembolism, other conditions aggravated by fluid retention. Renal impairment. Past ectopic pregnancy. Breastfeeding women should wait 6 wk after giving birth.

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Adverse Reactions

GI disturbances, appetite or wt changes, fluid retention, edema, acne, chloasma (melasma), allergic skin rashes, urticaria, mental depression, breast changes including discomfort or gynecomastia (occasionally), changes in libido, hair loss, hirsutism, fatigue, drowsiness, insomnia, fever, headache, premenstrual syndrome-like symptoms, altered menstrual cycles or irregular menstrual bleeding, inj-site reactions; altered serum lipid profile.

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Drug Interactions

Affected effectiveness w/ antibacterial that induce liver enzyme production. Markedly reduced plasma conc w/ aminoglutethimide. May inhibit ciclosporin metabolism leading to increased plasma-ciclosporin conc & risk of toxicity. Antidiabetics.

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Storage

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Description

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Action

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MIMS Class

Depot Contraceptives / Oestrogens, Progesterones & Related Synthetic Drugs

ATC Classification

G03AC06 - medroxyprogesterone ; Belongs to the class of progestogens. Used as systemic contraceptives.

Regulatory Classification

Presentation/Packing

Form

Depotrust depot inj 50 mg/mL

Packing/Price

3 mL x 1's

Depotrust

medroxyprogesterone

Manufacturer:

DKT

Distributor:

DKT