Deperin Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Sertraline HCl

Indications/Uses

Treatment of depression; obsessive-compulsive disorder; panic disorder w/ or w/o agoraphobia, social anxiety & post-traumatic stress disorder; premenstrual dysphoric disorder.

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Dosage/Direction for Use

Treatment of depression Initially 50 mg daily, may be increased if necessary in increments of 50 mg at intervals of at least 1 wk. Max: 200 mg daily. Obsessive-compulsive disorder Adult & adolescent Initially 50 mg daily. Childn 6-12 yr Initially 25 mg once daily. Panic disorder w/ or w/o agoraphobia, social anxiety & post-traumatic stress disorder Initially 25 mg daily. Thereafter, doses in all disorders may be increased if necessary in increments of 50 mg at intervals of at least 1 wk. Max: 200 mg daily. Premenstrual dysphoric disorder Initially 50 mg daily either throughout the menstrual cycle or during the luteal phase. Doses may be increased by 50 mg each menstrual cycle up to a max of 150 mg daily for continuous dosing or 100 mg daily when dosing during the luteal phase only. Patient who require 100 mg daily during luteal phase only dosing should initially be given 50 mg daily for the 1st 3 days of each luteal phase dosing period.

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Overdosage

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Administration

May be taken with or without food.

Contraindications

Hypersensitivity. Do not use in concomitant w/ MAOIs.

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Special Precautions

Monitor for menstrual irregularities, erythema multiforme & pancreatitis. Patients w/ hepatic or renal impairment. Pregnancy & lactation. Not for childn & adolescent <18 yr w/ major depressive disorder.

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Use In Pregnancy & Lactation

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Adverse Reactions

Headache, insomnia, agitation, anorexia, tremor. BP pressure disturbances; abnormal vision; vomiting, abdominal pain; amnesia, drowsiness, movement disorders paraesthesia, hypoaesthesia, depressive symptoms, hallucinations, aggressive reaction, anxiety, psychosis, depersonalisation nervousness, panic reaction & signs & symptoms associated w/ serotonin syndrome; seizures, arthralgia, myalgia; asymptomatic elevations in serum transaminases (SGOT & SGPT); urinary retention; hyperprolactinemia, galactorrhea, menstrual irregularities, anorgasmy; rash, angioedema, ecchymoses, pruritus & anaphylactoid reactions; malaise; w/drawal reactions.

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Drug Interactions

Risk of hyperthermia, rigidity, myoclonus, automatic instability w/ possible rapid fluctuations of vital signs, mental status changes that include confusion, irritability & extreme agitation progressing to delirium & coma w/ MAOIs. Increased plasma levels of TCAs & pimozide. Possible pharmacodynamic interaction w/ lithium & tryptophan. Enhancement of 5-HT-associated effects w/ serotonergic drugs (eg, tramadol, sumatriptan or fenfluramine). Potential increase in prothrombin time w/ warfarin. Possible serotonergic potentiation w/ St. John's wort. Decreased clearance w/ cimetidine.

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Storage

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Description

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Action

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MIMS Class

Antidepressants

ATC Classification

N06AB06 - sertraline ; Belongs to the class of selective serotonin reuptake inhibitors. Used in the management of depression.

Regulatory Classification

Presentation/Packing

Form

Deperin FC tab 50 mg

Packing/Price

50's (P29.46/film-coated tab, P1,473.21/box)

Deperin

sertraline

Manufacturer:

Psychotropics India

Distributor:

JF Draf