Cap Adult 600-1,800 mg/day divided in 2, 3 or 4 equal doses.
Childn >1 mth who can swallow cap 8-25 mg/kg/day in 3 or 4 equal doses.
Granules for oral soln Childn >1 mth 8-25 mg/kg/day in 3 or 4 equal doses.
Childn ≤10 kg Min recommended dose: 37.5 mg tid.
Inj Adult 2,400-2,700 mg IM/IV given in 2, 3, or 4 equal doses for intra-abdominal area, female pelvis, & other complicated or serious infections. 1,200-1,800 mg IM/IV daily in 3 or 4 equal doses for less complicated infections due to more susceptible microorganisms.
Childn >1 mth 20-40 mg/kg/day in 3 or 4 equal doses.
Neonate <1 mth 15-20 mg/kg/day in 3 or 4 equal doses.
β-hemolytic streptococcal infection Follow previously mentioned dosage recommendation for adult, childn, & neonate. Continue treatment for at least 10 days.
Pelvic inflammatory disease 900 mg IV every 8 hr daily + antibiotic IV w/ an appropriate gm -ve aerobic spectrum. Continue IV for at least 4 days & at least 48 hr after improvement, then continue w/ oral dose 450-600 mg every 6 hr daily to complete 10-14 days total therapy.
Chlamydia trachomatis cervicitis Cap 450-600 mg qid for 10-14 days.
Toxoplasmic encephalitis in AIDS patient Cap/inj 600-1,200 mg orally or IV every 6 hr for 2 wk followed by 300-600 mg orally every 6 hr. Usual total duration: 8-10 wk. Pyrimethamine dose: 25-75 mg orally each day for 8-10 wk. Folinic acid dose: 10-20 mg/day w/ higher doses of pyrimethamine.
Pneumocystis carinii pneumonia in AIDS patient Cap 300-450 mg every 6 hr & primaquine 15-30 mg once daily for 21 days.
Inj 600-900 mg IV every 6 hr or 900 mg IV every 8 hr & primaquine 15-30 mg orally once daily for 21 days.
Acute streptococcal tonsillitis/pharyngitis Cap 300 mg bid for 10 days.
Uncomplicated malaria/P. falciparum Cap/granules for oral soln Adult Quinine sulfate 650 mg tid for 3 or 7 days + clindamycin 20 mg base/kg/day divided tid for 7 days.
Childn Quinine sulfate 10 mg/kg tid for 3 or 7 days + clindamycin 20 mg base/kg/day divided tid for 7 days.
Severe malaria Cap/granules for oral soln Adult Quinidine gluconate 10 mg/kg loading dose IV over 1-2 hr, then 0.02 mg/kg/min continuous infusion for at least 24 hr. Once parasite density <1% & patient can take oral medication, complete treatment w/ oral quinine, same dosing regimen as uncomplicated malaria + clindamycin 20 mg base/kg/day divided tid for 7 days. If patient is not able to take oral medication, give 10 mg base/kg clindamycin loading dose IV followed by 5 mg base/kg IV every 8 hr. Switch to oral clindamycin as soon as patient can take oral medication. Treatment course: 7 days.
Childn Quinidine gluconate same dosing as for adults + clindamycin 20 mg base/kg/day divided tid for 7 days. If patient is not able to take oral medication, give 10 mg base/kg clindamycin loading dose IV followed by 5 mg base/kg IV every 8 hr. Switch to oral clindamycin as soon as patient can take oral medication. Treatment course: 7 days.
Prophylaxis of endocarditis in penicillin-sensitive patient Cap/granules for oral soln Adult 600 mg 1 hr before procedure.
Childn20 mg/kg 1 hr before procedure.
Inj 600 mg IV 1 hr before procedure.
Prophylaxis of head & neck surgery infection Inj 900 mg diluted in 1,000 mL normal saline as an intraoperative irrigant prior to wound closure.
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