OA 200 mg daily as single or in 2 divided doses. May be increased to 200 mg bid, if necessary. RA 100-200 mg bid. Ankylosing spondylitis Initially 200 mg daily as single or in 2 divided doses. May be increased to 400 mg daily after 6 wk. Pain & dysmenorrhea Initially 400 mg followed by 200 mg on the 1st day thereafter, 200 mg bid. Adjunct therapy to reduce adenomatous colorectal polyps in patient w/ familial adenomatous polyposis (FAP) 400 mg bid.
May be taken with or without food: Higher doses (eg, 400 mg bid) should be taken w/ meals to improve absorption. For childn w/ difficulty on swallowing cap, the contents of the cap may be added to applesauce. Empty the contents of the entire cap onto a level tsp of cool or room temp applesauce & ingest immediately w/ water.
Contraindications
Hypersensitivity to celecoxib or sulfonamides; aspirin or other NSAIDs. History of CVA, MI, uncontrolled HTN, CHF (NYHA II-IV); NSAID-induced asthma, urticaria or allergic-type reactions. Inflammatory bowel disease, renal impairment (CrCl <30 mL/min), severe hepatic impairment (Child-Pugh class C). Perioperative pain in CABG surgery.
Increased risk of serious GI events eg, bleeding, ulceration & perforation of stomach or intestines. History of ischemic heart disease or cerebrovascular disease. Significant risk factors for CV disease or peripheral arterial disease. Discontinue use if signs or symptoms of organ toxicity develop & in appearance of skin rash & signs of hypersensitivity. Dehydrated patients. Elderly.
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