Coveram Contraindications

Linked to perindopril: Hypersensitivity to the active substance or to any other ACE inhibitor; History of angioedema associated with previous ACE inhibitor therapy; Hereditary or idiopathic angioedema; Second and third trimesters of pregnancy; Concomitant use of Perindopril arginine + Amlodipine besilate (COVERAM) with aliskiren-containing products in patients with diabetes mellitus or renal impairment (GFR < 60 mL/min/1.73 m²); Concomitant use with sacubitril/valsartan (must not be initiated earlier than 36 months after the last dose of sacubitril/valsartan); Extracorporeal treatments leading to contact of blood with negatively charged surfaces; Significant bilateral renal artery stenosis or stenosis of the artery to a single functioning kidney.
Linked to amlodipine: Severe hypotension; Hypersensitivity to the active substance or to dihydropyridines derivatives; Shock, including cardiogenic shock; Obstruction of the outflow-tract of the left ventricle (e.g. high grade aortic stenosis); Hemodynamically unstable heart failure after acute myocardial infarction.
Linked to Perindopril arginine + Amlodipine besilate (COVERAM): All contraindications related to each monocomponent, as listed previously, should apply also to the fixed combination of Perindopril arginine + Amlodipine besilate (COVERAM).
Hypersensitivity to any of the excipients.