Contractubex Gel Mechanism of Action

Pharmacotherapeutic category: Anti-cicatricial/Anti-inflammatory. ATC code: D03AX.
Pharmacology: Pharmacodynamics: Extract Cepae + Heparin Sodium + Allantoin (Contractubex) Gel has an antiproliferative, antiphlogistic, loosening and smoothing effect on scar tissue. Extract cepae acts as an antiphlogistic by inhibiting the release of inflammation mediators and has an antiallergic effect. Extract cepae inhibits the growth of fibroblasts of various origins and of keloid fibroblasts in particular. In addition to a mitogenic inhibitory effect, the drug has been shown to diminish the formation of extracellular matrix constituents from fibroblasts (e.g. proteoglycans). Extract Cepae has a bactericidal action. These properties stimulate primary wound healing and counteract unphysiological scar formation. Heparin is antiphlogistic, antiallergic, antiproliferative and increases tissue hydration. It also has a loosening effect on collagen structure. For the treatment of scars, the anti-inflammatory effect of heparin and its effect on the constituents of the connective tissue matrix are more important than its known antithrombotic action. Allantoin promotes wound healing; it has an epithelialising effect and increases the tissue's water-binding capacity. In addition, its keratolytic and penetration-promoting properties improve the efficacy of the other active ingredients of Extract Cepae + Heparin Sodium + Allantoin (Contractubex) Gel. Allantoin has a soothing effect, which relieves the pruritus often associated with scar formation. The synergistic effect of this combination of active ingredients lies in the super additive inhibition of fibroblast proliferation and especially of pathologically increased collagen synthesis.
Toxicology: Preclinical Safety Data: According to present knowledge, there is no toxicological risk, especially with regard to mutagenic, teratogenic and carcinogenic effects.