Bisoprolol (Concore) is contraindicated in patients with: acute heart failure or during episodes of heart failure decompensation requiring i.v. inotropic therapy; shock induced by disorders of cardiac function (cardiogenic shock); severe disturbances of atrioventricular conduction (second or third degree AV block) without a pacemaker; sick sinus syndrome; sinoatrial block; slowed heart rate, causing symptoms (symptomatic bradycardia); decreased blood pressure, causing symptoms (symptomatic hypotension); severe bronchial asthma; severe forms of peripheral arterial occlusive disease or Raynaud's syndrome; untreated tumors of the adrenal gland (pheochromocytoma); metabolic acidosis; hypersensitivity to bisoprolol or to any of the excipients.
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