Concore AM Dosage/Direction for Use

Bisoprolol + Amlodipine (Concore AM) is indicated in patients whose blood pressure is adequately controlled with separately administered mono-component products of the same doses as the recommended fixed dose combination.
The recommended daily dose is one tablet of the given strength.
Bisoprolol + Amlodipine (Concore AM) is indicated in patients whose blood pressure is not adequately controlled with bisoprolol or amlodipine alone.
Treatment with Bisoprolol + Amlodipine (Concore AM) is started with the lowest dose of Bisoprolol + Amlodipine (Concore AM) 5 mg/5 mg for the first 6 weeks. After 6 weeks, the dosage for patients with uncontrolled blood pressure may be increased to Bisoprolol + Amlodipine (Concore AM) 5 mg/10 mg or Bisoprolol + Amlodipine (Concore AM) 10 mg/5 mg according to tolerability. After further 6 weeks, the dosage for patients with uncontrolled blood pressure may be increased to Bisoprolol + Amlodipine (Concore AM) 10 mg/10 mg. For patients who are not tolerating their increased dose, their dose should be down titrated to their prior dose. The recommended daily dose is one tablet of the given strength.
Treatment with Bisoprolol + Amlodipine (Concore AM) must not be stopped abruptly, since the abrupt withdrawal of bisoprolol may lead to a transitory worsening of clinical condition. Especially in case of patients with ischemic heart disease, treatment must not be discontinued suddenly. Gradual reduction of the daily dose is recommended.
Elderly: No dosage adjustment is required. However, caution is advised when the dose is increased.
Pediatric patients: There is no experience with Bisoprolol + Amlodipine (Concore AM) in the pediatric population. Therefore, its use cannot be recommended.
Renal impairment: No dosage adjustment is required for patients with mild to moderate renal impairment.
In case of severe renal impairment (creatinine clearance < 20 mL/min), the daily dose of the bisoprolol component of Bisoprolol + Amlodipine (Concore AM) must not exceed 10 mg.
Hepatic impairment: In case of severe hepatic impairment, the daily dose of the bisoprolol component in Bisoprolol + Amlodipine (Concore AM) must not exceed 10 mg.
Due to the amlodipine component, in case of hepatic impairment, special caution must be taken when Bisoprolol + Amlodipine (Concore AM) is administered.
Administration: Tablets are taken in the morning with or without food. They are swallowed with some liquid and not to be chewed.