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Caution must be exercised when using Ebastine in patients known to be at cardiac risk such as those with long QT syndrome, hypokalemia, treatment with any drug known to produce an increase in QT interval or inhibit CYP3A4 enzyme systems such as azole antifungals and macrolide antibiotics.
Betamethasone should only be used systematically with great caution in the presence of heart failure, recent myocardial infarction or hypertension, in patients with diabetes mellitus, epilepsy, glaucoma, hypothyroidism, hepatic failure, osteoporosis, peptic ulceration, psychoses or severe affective disorders and renal impairment.
Effects on Ability to Drive and Use of Machines: In man, psychomotor function has been investigated extensively and no effect was found at recommended therapeutic doses.
A study focused on car driving ability indicated that Ebastine did not induce any driving impairment even at 30 mg. Based on these results, Ebastine at recommended therapeutic doses does not affect the ability to drive or operate machines.
The cardiac effects of Ebastine alone have been investigated in clinical studies. No significant cardiac effects have been observed, in detailed analyses, at doses up to 100 mg per day (five times the recommended daily dose).
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