Clonotril-0.5/Clonotril-2 Dosage/Direction for Use

Treatment should be started with low doses. The dose may be increased progressively until the maintenance dose suited to the individual patient has been found. The maintenance dosage must be determined according to clinical response and tolerance.
Initial Dose: Adults: Initial dose of 1 mg by mouth in the evening. Children: Initial dosage should not exceed 0.25 mg/day for infants and small children (1 to 5 years old) and 0.5 mg/day for older children (6 to 12 years old). Or as prescribed by the physician.
Maintenance: Adults: 4 to 8 mg daily in three or four divided doses. Children: 6 to 12 years old: 3 to 6 mg, 1 to 5 years old: 1 to 3 mg, 0 to 1 year old: 0.5 to 1 mg, or as prescribed by the physician.
Once the maintenance dose has been reached, the daily amount maybe given as a single dose in the evening. Should several doses be necessary, the largest should be taken in the evening. The maintenance dose level is attained after 1 to 3 weeks of treatment. The maximum daily therapeutic dose for adults is 20 mg while in children is 200 mcg/kg body weight.
Combination with other Antiepileptics: Simultaneous administration of more than one antiepileptic drug are a common practice in the treatment of epilepsy, especially in those who cannot tolerate high doses of single medication. Clonazepam in such patients can be given in combination. The dosage of each drug may be required to be adjusted to obtain the optimum effect.