Pharmacology:Pharmacokinetics: Clonidine is well absorbed from the gastrointestinal tract, and peak plasma concentrations occur about 3 to 5 hours after an oral dose. It is about 20 to 40% protein bound. About 50% of a dose metabolized in the liver. It is excreted in the urine as unchanged drug and metabolites, 40 to 60% of an oral dose being excreted in 24 hours as unchanged drug; about 20% of a dose is excreted in the faeces, probably via enterohepatic circulation. The elimination half-life has been variously reported to range between 6 and 24 hours, extended to up to 41 hours in patients with renal impairment. Clonidine crosses the placenta and is distributed into breast milk.
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