Citrapos/Citrapos XR

Management of renal tubular acidosis w/ Ca stones, hypocitraturic Ca oxalate nephrolithiasis of any etiology, & uric acid lithiasis w/ or w/o Ca stones.

Severe hypocitraturia (urinary citrate <150 mg/day) Initially 60 mEq daily (20 mEq tid or 15 mEq qid). Mild to moderate hypocitraturia (>150 mg/day) Initially 30 mEq daily (10 mEq tid).

Should be taken with food: Take w/ meals or w/in 30 min after meals or bedtime snack. Swallow whole, do not crush/chew/suck.

Patients w/ hyperkalemia or conditions predisposing to hyperkalemia eg, chronic renal failure, uncontrolled DM, acute dehydration, strenuous physical exercise in unconditioned individuals, adrenal insufficiency, extensive tissue breakdown, or administration of K-sparing agent (eg, triamterene, spironolactone or amiloride). Patients suffering from delayed gastric emptying, esophageal compression, intestinal obstruction or stricture, or taking anticholinergic medication. Not to be given to patients w/ PUD. Renal insufficiency (GFR <0.7 mL/kg/min).

Hyperkalemia & cardiac arrest in patients w/ impaired mechanisms for excreting K. Potentially fatal hyperkalemia can develop rapidly & be asymptomatic. Avoid use in patients w/ chronic renal failure, or other condition which impairs K excretion eg, severe myocardial damage or heart failure. Discontinue immediately & investigate possibility of bowel perforation or obstruction if there is severe vomiting, abdominal pain or GI bleeding. Use 24 hr urinary citrate &/or pH measurements to determine adequacy of initial dosage & to evaluate effectiveness of any dosage change. Measure urinary citrate &/or pH every 4 mth. Pregnancy & lactation. Citrapos Avoid concomitant administration w/ K-sparing diuretic (eg, triamterene, spironolactone or amiloride). Patient taking both diuretics & digitalis prep, or having trouble swallowing tab or if tab sticks in throat, tarry stools or other evidence of GI bleeding. Childn. Citrapos XR Closely monitor for signs of hyperkalemia w/ periodic blood tests & ECG. Reports of upper GI mucosal lesions.

Minor GI complaints eg, abdominal discomfort, vomiting, diarrhea, loose bowel movements or nausea. Intact matrices in feces.

May produce severe hyperkalemia w/ K-sparing diuretic (eg, triamterene, spironolactone or amiloride).

Other Drugs Acting on the Genito-Urinary System

A12BA02 - potassium citrate ; Belongs to the class of potassium-containing preparations. Used as dietary supplements.

Rx