Ciprophil Adverse Reactions

Among the usual adverse effects of ciprofloxacin are gastrointestinal disturbances, central nervous system (CNS) toxicity and hypersensitivity reactions.
Nausea, vomiting, diarrhea, abdominal pain, and dyspepsia are experienced as common gastrointestinal disturbances. Reports of pseudomembranous colitis are seldom received. Headache, anorexia, flatulence, bilirubinemia, dizziness, and restlessness are the most common CNS effects. Other CNS toxicity associated with the use of ciprofloxacin are tremor, drowsiness, insomnia, agitation, confusion, unpleasant dreams, visual disturbances and other sensory disturbances, hallucinations, depression and convulsions, eosinophilic meningitis, acute pyschoses, peripheral neuropathy, dysaethesia, catatonia, hemisparesis and tinnitus.
Patients taking ciprofloxacin may also experience hypersensitivity reactions such as rash, pruritus, photosensitivity, vasculitis, erythema multiforme; Stevens-Johnson syndrome, toxic epidermal necrolysis, laryngeal edema and anaphylaxis (may be fatal). Reversible arthralgia and joint erosions were seen in animals. A case of tendon damage was also reported. Reports of transient elevation of serum creatinine, blood urea nitrogen and liver enzyme values, acute renal failure secondary to interstitial nephritis, crystalluria, jaundice, moniliasis, asthenia, hepatitis, eosinophilia, leucopenia, thrombocytopenia, pancytopenia, haemolytic anemia or agranulocytosis, myalgia and gynecomastia were received. Tachycardia, edema, syncope, hot flushes and sweating are among the cardiovascular effects of the use of ciprofloxacin.
Pseudomembranous colitis and super infection with Candida, Clostridium difficile, and Streptococcus pneumoniae associated with the use of ciprofloxacin were reported. The risk of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci colonization are high in patients taking ciprofloxacin.