Cipromet Special Precautions

Gastrointestinal System: In the event of severe and persistent diarrhea during or after treatment, a physician must be consulted, since this symptom can hide a serious intestinal disease (life threatening pseudomembranous colitis with possible fatal outcome), requiring immediate treatment. In such cases, Ciprofloxacin must be discontinued and appropriate therapy initiated. Drugs that inhibit peristalsis are contraindicated. There can be a temporary increase in transaminases, alkaline phosphates or cholestatic jaundice, especially in patients with previous liver damage.
Nervous System: In epileptics and in patients who have suffered from previous CNS-disorders (e.g. lowered convulsion threshold, previous history of convulsion, reduced cerebral blood flow, altered brain structure or stroke), Ciprofloxacin should only be used when the benefits of treatment exceed the risks, since these patients are endangered because of possible central-nervous adverse effects.
In some instances the CNS reactions occurred after the first administration of Ciprofloxacin already. In rare cases, depression or psychosis can progress to self-endangering behavior. In these cases, Ciprofloxacin has to be discontinued and the physician should be informed immediately.
Hypersensitivity: In some instances, the hypersensitivity and allergic reactions already occurred after the first administration and in very rare instances anaphylactic/anaphylactoid reactions can progress to a life threatening shock. In these cases Ciprofloxacin has to be discontinued and the physician must be immediately notified.
Musculoskeletal System: At any sign of tendonitis (e.g. painful swelling) the administration of Ciprofloxacin should be discontinued, physical exercise should be avoided, and a physician should be consulted.
Tendon rupture (predominantly Achilles tendon) has been reported predominantly in the elderly on prior treatment with glucocorticoids.
Skin and Appendages: Ciprofloxacin has been shown to produce photosensitivity reactions. Patients taking Ciprofloxacin should avoid direct exposure to excessive sunlight or UV-light. Therapy should be discontinued if photosensitisation (i.e. Sunburn-like reactions) occurs.
Ability to Drive and Use of Machines: Even when the drug is taken exactly as prescribed, it can affect the speed of reactions to such an extent that the ability to drive or to operate machines is impaired. This applies particularly in combination with alcohol.