Ciflomed Special Precautions

In epileptics and in patients who have suffered from previous CNS disorders (e.g. lowered convulsion threshold, previous history of convulsion, reduced cerebral blood flow, altered brain structure or stroke), Ciprofloxacin should only be used where the benefits of treatment exceed the risks, since these patients are endangered because of possible central nervous side effects.
Do not use Ciprofloxacin simultaneously with antacid preparations containing Magnesium Hydroxide or Aluminium Hydroxide. An interval of at least 2 hours must be respected between the administration of an antacid and Ciprofloxacin.
Patients receiving Ciprofloxacin must be well hydrated to prevent crystalluria.
Excessive alkalinisation of urine should be avoided.
When Xanthine derivatives like theophylline were co-administrated with Ciprofloxacin the plasma levels of theophylline were raised to the toxic range. In this case suitable dose reduction of theophylline may be considered.