Cerebrolysin Mechanism of Action

Pharmacology: Cerebrolysin is a multi-modal neuropeptide drug with a fast onset of action that helps to regain and maintain the independence of patients suffering from stroke, TBI, dementia and cognitive impairment.
Cerebrolysin improves the brain's ability for self-repair by stimulating neurorecovery.
Cerebrolysin is effective, safe and well-tolerated as shown in clinical studies including randomized, double-blind, controlled trials.
Cerebrolysin is of European/Austrian quality.
Mode of Action: Cerebrolysin is a neurotrophic peptidergic drug with multimodal pharmacological properties and is indicated for the treatment of acute and chronic central nervous system (CNS) disorders. Cerebrolysin counteracts the pathophysiological mechanisms by: Support of endogenous repair and recovery processes as a consequence of injury or degenerative diseases.
Protection against pathological events and cascades caused by an injury or a degenerative disease. (See Figure 1.)

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The natural repair and recovery processes in the CNS start immediately upon injury and play an important role in the continuous defense against neurodegeneration in chronic CNS disorders (e.g. Alzheimer's disease). Cerebrolysin has shown to modify two major signalling pathways: the neurotrophic factor (NTF) and sonic hedgehog (Shh) signalling pathway. These pathways regulate on a molecular level the cellular processes of neurogenesis, angiogenesis, dendrite arborisation, axonal sprouting, myelination, and integrity of the neurovascular unit, thereby supporting the maintenance and repair of the neuronal network.
The pathological events and cascades after stroke or trauma lead to secondary injuries, which further compromise motor and cognitive functions of a patient. Among the most relevant molecular processes targeted by Cerebrolysin in the acute phase of an injury are events of the ischemic cascade, like Excitotoxicity; Uncontrolled apoptosis; Overactivation of proteolytic enzymes; Overproduction of reactive oxygen species (ROS).
In the early post-acute phase, Cerebrolysin prevents formation of toxic protein aggregates and lowers the level of inflammatory processes, both linked to neurodegeneration if not prohibited.