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Carvedilol is a non-cardioselective beta-blocker. It has vasodilating properties, which are attributed mainly to its blocking activity at alpha-1 receptors; at higher doses calcium-channel blocking activity may contribute. It has also antioxidant properties. Carvedilol is reported to have intrinsic sympathomimetic activity and only weak membrane-stabilising activity.
Carvedilol is used in the management of hypertension and angina pectoris, and as an adjunct to standard therapy in sympathomimetic heart failure. It is also used to reduce mortality in patients with left ventricular dysfunction after myocardial infarction.
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