Carvex Dosage/Direction for Use

In hypertension, an initial dose of 12.5 mg once daily by mouth, increased after 2 days to 25 mg once daily. Alternatively, an initial dose of 6.25 mg is given twice daily, increased after one to two weeks to 12.5 mg twice daily. The dose may be increased further, if necessary, at intervals of at least 2 weeks to 50 mg once daily or in divided doses. A dose of 12.5 mg once daily may be adequate for elderly patients.
In angina pectoris, an initial dose of 12.5 mg is given twice daily by mouth, increased after two days to 25 mg twice daily.
In heart failure, the initial dose is 3.125 mg twice daily by mouth. It should be taken with food to reduce the risk of hypotension. If tolerated, the dose should be doubled after 2 weeks to 6.25 mg twice daily and then increased gradually, at intervals of not less than 2 weeks, to the maximum dose tolerated by the patient; this should not exceed 25 mg twice daily in patients weighing less than 85 Kg or 50 mg twice daily in patients weighing more than 85 Kg. Patients should be monitored for 2-3 hours after initiation and after each dose increase.
This drug should be administered to patients with left ventricular ejection fraction less than 45% and cardiac rate more than 65 times/min during a break and stable patients having fundamental treatment of angina at least before 4 weeks (in case of no change to NYHA class or basic treatment and no occurrence of hospitalization by aggravation of symptoms).
In case of every up-titration, physician should certainly check whether aggravation of cardiac failure and side effects by vasodilatation (e.g. descending blood pressure and dizziness) to patients, regular medical examination (e.g. renal function, weight, blood pressure and cardiac rate etc.) should be instituted. In congestive heart failure patients, worsening cardiac failure or fluid retention may occur during up-titration of carvedilol. If such symptoms occur, diuretic should be increased and the carvedilol dose should not be advanced until clinical stability resumes. Occasionally, it may be necessary to lower the carvedilol dose or temporarily discontinue it. When given again after discontinuing administration over 2 weeks, it should start from initial dose (3.12 mg, twice a day).
Or as prescribed by the physician.
The safety and efficacy of carvedilol in patients under 18 years have not been established.