Carmepem Dosage/Direction for Use

500 mg every 8 hours by intravenous infusion over 15 minutes to 30 minutes for skin and skin structure infections for adult patients. When treating infections caused by Pseudomonas aeruginosa, a dose of 1 gram every 8 hours is recommended.
1 gram every 8 hours by intravenous infusion over 15 minutes to 30 minutes for intra-abdominal infections for adult patients.
1 gram every 8 hours by intravenous bolus injection (5 mL to 20 mL) over 3 minutes to 5 minutes for adult patients.
Dosage should be reduced in adult patients with renal impairment. (See Table 2.)

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Pediatric patients 3 months of age and older: (See Table 3.)

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Pediatric patients less than 3 months of age: (See Table 4.)

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Preparation of Solution: For Intravenous Bolus Administration: Constitute injection vials (500 mg and 1 gram) with sterile Water for injection. See table below. Shake to dissolve and let stand until clear. (See Table 5.)

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For Infusion: Infusion vials (500 mg and 1 gram) may be directly constituted with a compatible infusion fluid. Alternatively, an injection vial may be constituted, then the resulting solution added to an intravenous container and further diluted with an appropriate infusion fluid (see Dosage and Administration as follows.)
WARNING: Do not use flexible container in series connections.
Compatibility: Compatibility of Meropenem with other drugs has not been established. Meropenem should not be mixed with or physically added to solutions containing other drugs.
Stability and Storage: Freshly prepared solutions of Meropenem should be used. However, constituted solutions of Meropenem maintain satisfactory potency under the conditions described as follows. Solutions of intravenous Meropenem should not be frozen.
Intravenous Bolus Administration: Meropenem Powder for injection (IV) vials constituted with sterile Water for injection for bolus administration (up to 50 mg/mL of Meropenem) may be stored for up to 3 hours at up to 25°C (77°F) or for 13 hours at up to 5°C (41°F).
Intravenous Infusion Administration: Solutions prepared for infusion (Meropenem Powder for lnjection (IV) concentrations ranging from 1 mg/mL to 20 mg/mL) constituted with Sodium Chloride injection 0.9% may be stored for 1 hour at up to 25°C (77°F) or 15 hours at up to 5°C (41°F).
Solutions prepared for infusion (Meropenem Powder for lnjection (IV)) concentrations ranging from 1 mg/mL to 20 mg/mL) constituted with Dextrose injection 5% should be used immediately.
NOTE: Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.