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Hypersensitivity to metoprolol or any other beta-blocker or any component of the product.
Severe bronchial asthma or history of severe bronchospasm.
Hypotension.
Metabolic acidosis.
Hypertensive and angina patients with the following conditions: Sinus bradycardia; Heart block greater than first degree; Cardiogenic shock; Overt or decompensated cardiac failure; Sick sinus syndrome; Severe peripheral arterial circulatory disorders; Untreated pheochromocytoma.
Patients with acute myocardial infarction who have the following conditions: Heart rate <45 beats/minute; Second- and third-degree heart block; Significant first degree heart block (P-R interval ≥0.24 sec); Systolic blood pressure <100 mmHg; Moderate to severe cardiac failure.
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