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Antacid: Aluminum hydroxide- and magnesium hydroxide-containing antacid cause a small increase in plasma concentration of Capecitabine and one metabolite (5'-DFCR).
Coumarin Anticoagulants: Patients taking coumarin-derivative anticoagulants concomitantly with Capecitabine should be monitored regularly for alterations in their coagulation parameters.
Phenytoin: The level of phenytoin should be carefully monitored in patients taking Capecitabine and phenytoin dose may need to be reduced.
Leucovorin: The concentration of 5-fluorouracil is increased and its toxicity may be enhanced by Leucovorin.
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