Avoid in patients w/ Ca renal stones or history of kidney stones. Dose spacing of at least 3 hr if used w/ fluoroquinolones & tetracyclines. Monitor plasma Ca conc when used w/ vit D & thiazide diuretics due to increased risk of hypercalcemia. Patients w/ renal impairment.
Increased GI absorption w/ vit D. Decreased Ca urinary excretion w/ thiazide diuretics. Decreased absorption of Fe from Fe sulfate. Decreased estramustine absorption. Reduced intestinal absorption w/ fluoroquinolones & tetracycline. Reduced efficacy of levothyroxine.
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