Pharmacology: Pharmacokinetics: Sodium Ascorbate is readily absorbed from gastrointestinal tract and is widely distributed in the body tissues. Plasma concentrations of sodium ascorbate rise as the dose ingested is increased until a plateau is reached with doses of about 90 to 150 mg daily. Body stores of sodium ascorbate in healthy patient are about 1.5 g although more may be stored at intakes above 200 mg daily. The concentration is higher leucocytes and platelets than in erythrocytes and plasma. In deficiency states the concentration in leucocytes declines later and at a slower rate, and has been considered to be a better criterion for the evaluation of deficiency than the concentration in plasma. Sodium Ascorbate is reversible oxidised to dehydroascorbic acid; some is metabolised to ascorbate-2-sulfate which is inactive and oxalic acid which are excreted in the urine. Sodium Ascorbate in excess of the body's needs is also rapidly eliminated unchanged in the urine; this generally occurs within intakes exceeding 100 mg daily. Sodium ascorbate crosses the placenta and is distributed into breast milk. It is removed by haemodialysis.
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