The use of Silver Sulfadiazine is contraindicated in premature infants and neonates because of possible kernicterus. Silver Sulfadiazine should not be used in pregnancy, except in cases when the potentially life-saving benefits of the medication outweigh possible hazard to the fetus. Sensitization by silver sulfadiazine has not been reported in clinical studies. Only on theoretical grounds should attention be paid to the following possible contraindications of sulfonamides: hypersensitivity, liver damage and oliguria.