May increase sedating effects of CNS depressants eg, antipsychotics, anxiolytic sedatives, opioid analgesics, hypnotics, barbiturates & alcohol. Phenylephrine: Increased risk for toxicity w/ other sympathomimetics (eg, epinephrine); MAOIs (eg, sertraline, amitriptyline, imipramine); may decrease effect w/ adrenergic receptor blockers (eg, propranolol, phenothiazine, phentolamine).