Bexsero Drug Interactions

Use with other vaccines: Meningococcal Group B Vaccine (Bexsero) can be given concomitantly with any of the following vaccine antigens, either as monovalent or as combination vaccines: diphtheria, tetanus, acellular pertussis, Haemophilus influenzae type b, inactivated poliomyelitis, hepatitis B, heptavalent pneumococcal conjugate, measles, mumps, rubella, varicella, and meningococcal groups A, C, W, Y conjugate.
Clinical studies demonstrated that the immune responses of the co-administered routine vaccines were unaffected by concomitant administration of Meningococcal Group B Vaccine (Bexsero). Inconsistent results were seen across studies for responses to inactivated poliovirus type 2 and pneumococcal conjugate serotype 6B but these data do not suggest clinically significant interference.
The safety profiles of the co-administered vaccines were unaffected by concomitant administration of Meningococcal Group B Vaccine (Bexsero) with the exception of more frequent occurrence of fever, tenderness at the injection site, change in eating habits and irritability. Prophylactic use of paracetamol reduces the incidence and severity of fever without affecting the immunogenicity of either Meningococcal Group B Vaccine (Bexsero) or routine vaccines. The effect of antipyretics other than paracetamol on the immune response has not been studied.
Concomitant administration of Meningococcal Group B Vaccine (Bexsero) with vaccines other than those mentioned above has not been studied.
Administration of vaccines containing whole cell pertussis concomitantly with Meningococcal Group B Vaccine (Bexsero) has not been studied and thus is not recommended.
When given concomitantly with other vaccines Meningococcal Group B Vaccine (Bexsero) must be administered at separate injection sites (see Method of Administration under Dosage & Administration).