Contraindicated to patients with known hypersensitivity to carvedilol, or other component of the product, unstable/decompensated heart failure; clinically manifest liver dysfunction. Patients with 2nd or 3rd degree atrioventricular (AV) block (unless a permanent pacemaker is in place); severe bradycardia (<50 bpm); sick sinus syndrome (including sino-atrial block); severe hypotension (systolic <85 mmHg); cardiogenic shock and history of bronchospasm or asthma.