May enhance the antihypertensive effects of other antihypertensive drugs such as beta blockers although the combination is generally well tolerated. Enhanced antihypertensive effects may also be seen with concomitant use of drugs such as aldesleukin and antipsychotics that cause hypotension. Nifedipine may modify insulin and glucose responses and therefore diabetic patients may need to adjust their antidiabetic treatment when receiving amlodipine. It is extensively metabolized in the liver by the cytochrome P450 enzyme system, and interactions may occur with other drugs such as quinidine sharing the same metabolic pathway and with enzyme inducers such as carbamazepine, phenytoin and rifampicin and enzyme inhibitors such as cimetidine and erythromycin.
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