Berocca Immuno Overdosage

Signs and Symptoms of Overdose: There is no evidence that this product can lead to an overdose when used as labeled.
Allowance should be made for intake of the Vitamins and Zinc from other sources.
General manifestations of overdose may include increase of gastrointestinal disturbances including diarrhea, nausea, and vomiting.
If such symptoms occur, the product should be stopped and a healthcare professional must be consulted.
Acute or chronic overdose of the product may cause specific toxicity associated with either Vitamin C, Vitamin D, and/or Zinc.
Clinical signs and symptoms, laboratory findings, and consequences of overdose are highly diverse, dependent on an individual's susceptibility, and surrounding circumstances. Specific clinical manifestation (i.e. with intake up to 10 times the labelled dose) may include the following: Ascorbic Acid (Vitamin C): Acute or chronic overdose of Vitamin C (>2 g/day in adults) may significantly elevate serum and urinary oxalate levels. In some instances, this results in hyperoxaluria, calcium oxalate crystalluria, calcium oxalate deposition, kidney stone formation, tubulointerstitial nephropathy, and acute renal failure. Overdose of Vitamin C in individuals with glucose-6-phosphate dehydrogenase deficiency (>3 g/day in children and >15 g/day in adults) may result in oxidative hemolysis or disseminated intravascular coagulation.
Cholecalciferol (Vitamin D₃): Chronic ingestion of Vitamin D in excess of 400 IU/day (100 mcg/day) increases risk of hypervitaminosis D. Many of the effects of chronic Vitamin D toxicity are due to induced hypercalcemia and hypercalciuria. Symptoms may include anorexia, nausea, vomiting, weight loss, polyuria, heart arrhythmia, fatigue and soft tissue calcification.
Material hypercalcemia, possibly caused excessive Vitamin D intake during pregnancy, has been associated with hypercalcemia in neonates, which may lead to supravalvular aortic stenosis syndrome, the failures of which may include retinopathy, mental or growth retardation, strabismus and other effects.
Zinc: Zinc overdose (>40 mg/day in adults) can cause diarrhea, irritation, and corrosion of the gastrointestinal (GI) tract, acute tubular necrosis, interstitial nephritis, copper deficiency, sideroblastic anemia and myeloneuropathies.
If overdose with the product is suspected, intake should be stopped and a healthcare professional consulted for treatment of clinical manifestations.
What to do when the patient has taken more than the recommended dosage: There is no specific antidote however patients should still consult their physician.