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Hypersensitivity to tramadol, paracetamol or to any of the excipients of the medicinal product.
Acute intoxication with alcohol, hypnotic drugs, centrally-acting analgesics, opioids or psychotropic drugs.
Severe respiratory depression (Light respiratory depression may occur).
Due to head injury or encephalopathy, patients with the risk of consciousness disturbance.
Patients who are receiving monoamine oxidase inhibitors or within two weeks of their withdrawal.
Peptic ulcer or severe blood disorder.
Severe liver disease, renal disorder or severe renal failure.
Patients with aspirin asthma (induction of asthmatic attack caused by NSAIDs) or history thereof.
Epilepsy not controlled by treatment.
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