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The antihypertensive effects of Losartan may be potentiated by drugs or other agents that lower blood pressure.
NSAIDs should be used with caution in patients taking Losartan as the risk of renal impairment may be increased.
NSAIDs may also attenuate the hypotensive effect of Losartan.
Losartan and some other angiotensin II receptor antagonists are metabolized by cytochrome P450 isoenzyme and interactions may occur with drugs that affect these enzymes.
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