Azithromycin is a nitrogen-containing macrolide or azalide with wide spectrum of activity that has been used in the treatment of a wide variety of infections caused by susceptible organisms. In lower respiratory tract infections including bronchitis due to Haemophilus influenzae, Moraxella catarhallis, Streptococcus pneumoniae or Staphylococcus aureus and pneumonia due to Streptococcus pneumoniae or Haemophilus influenza. It is also given in the treatment of respiratory tract infections (including otitis media), in skin and soft-tissue infections, and in uncomplicated genital infections. Azithromycin may also be used for the prophylaxis, and as a component regimen in the treatment of Mycobacterium avium complex (MAC). It is used in some countries for the prophylaxis of endocarditis in at risks patients unable to take penicillin. It is also used in the management of trachoma and typhoid.