Axialith Dosage/Direction for Use

The use of Axialith is not age-restricted.
The following daily dose is recommended for various indications: To dissolve gallstones: 250 mg Axialith: Approx 10 mg Ursodeoxycholic acid per kg body weight, equivalent to: Up to 60 kg 2 film-coated tablets (equivalent to 500 mg ursodeoxycholic acid); 61-80 kg 3 film-coated tablets (equivalent to 750 mg ursodeoxycholic acid); 81-100 kg 4 film-coated tablets (equivalent to 1,000 mg ursodeoxycholic acid); above 100 kg 5 film-coated tablets (equivalent to 1,250 mg ursodeoxycholic acid).
The film-coated tablets should be taken unchewed together with some liquid in the evening before going to bed.
The tablets must be taken at regular intervals.
The duration until the gallstones have dissolved is generally 6-24 months. If the gallstones have not reduced in size after 12 months, therapy should not be continued.
The success of treatment should be reviewed by sonography or x-ray every 6 months. It should be checked in the follow ups whether the stones have calcified in the meantime. If this is the case, treatment should be discontinued.
For symptomatic treatment of primary biliary cirrhosis (PBC): The daily dose depends on the body weight ad is between 3 and 7 film-coated tablets (250 mg Axialith) (14±2 mg ursodeoxycholic acid per kg body weight.
See table:

Click on icon to see table/diagram/image

Intake of Axialith for primary biliary cirrhosis (PBC) may be continued indefinitely.
In patients with primary biliary cirrhosis (PBC), clinical symptoms can worsen in rare cases at the beginning of treatment, eg the itching may increase. If this is the case, therapy should be continued with 1 film-coated tablet of 250 mg Axialith daily; therapy should be continued gradually (increase in the daily dose by 1 film-coated tablet of 250 mg Axialith per week) until the recommended dosage has been reached.