Discontinue if markedly creatinine phosphokinase levels occur or myopathy is diagnosed. Temporarily withheld or discontinue in patients with acute serious condition suggestive of myopathy or with risk factor predisposing to the development of renal failure secondary to rhabdomyolysis. Increased risk of recurrent hemorrhagic stroke. Increased HbA1c and fasting serum glucose levels. Monitor for increased transaminase levels until abnormalities resolve: signs and symptoms of muscle pain, tenderness or weakness.