Avancomycin 500 Caution For Usage

For single use only.
Preparation of Solution: At the time of use, add 10 mL of Sterile Water for Injection BP to a 500 mg vial of Vancomycin hydrochloride Powder for Concentrate for Infusion. Similarly, add 20 mL of Sterile Water for Injection BP to a 1 g vial of Vancomycin Hydrochloride Powder for Concentrate for Infusion. Vials reconstituted in this manner will give a solution of 50 mg/mL. Further dilution is required depending on method of administration:
(i) Intermittent infusion (the preferred method of administration): Reconstituted solutions containing 500 mg vancomycin must be diluted with at least 100 mL diluent. Reconstituted solutions containing 1 g vancomycin must be diluted with at least 200 mL diluent.
Sodium Chloride Intravenous Infusion B.P. or Dextrose Intravenous Infusion B.P. are suitable diluents. The desired dose should be administered by intravenous infusion at a rate of no more than 10 mg/min. If administered over a shorter period of time or in higher concentrations, there is a possibility of inducing marked hypotension in addition to thrombophlebitis. Rapid administration may also produce flushing and a transient rash over the neck and shoulders.
(ii) Continuous infusion (should only be used when intermittent infusion not feasible): 1 g or 2 g of vancomycin may be added to a sufficiently large volume of Sodium Chloride 0.9% Injection or Glucose 5% in Water for Injection to permit the desired dose to be infused over twenty-four hours.
Reconstitution Detail: Chemical and physical in-use stability has been demonstrated for 4 days at 2-8°C.
From a microbiological point of view, the product should be used immediately. If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2-8°C, unless reconstitution has taken place in controlled and validated aseptic conditions.