Avamax Overdosage

There is no specific treatment for atorvastatin overdose. In case of overdosage, discontinue use and institute appropriate symptomatic and supportive measures as needed. In symptomatic patients, monitor serum creatinine, blood urea nitrogen (BUN), CK, and urine myoglobin for indications of renal impairment secondary to rhabdomyolysis. Liver function tests should be performed.
Consider administration of activated charcoal in cases of significant ingestion. In patients who are not fully conscious or have impaired gag reflex, consideration should be given to administering activated charcoal via nasogastric tube once the airway is protected. For rhabdomyolysis, administer sufficient 0.9% saline to maintain urine output of 2 to 3 mL/kg/hr. Diuretics may be necessary to maintain urine output. Urinary alkalinization is not routinely recommended. Hemodialysis is not expected to significantly enhance atorvastatin clearance because of extensive drug binding to plasma proteins.