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Fibrate.
Pharmacology: Fenofibrate, a fibric acid derivative, is a lipid regulating drug with actions on plasma lipids.
Pharmacokinetics: Fenofibrate is readily absorbed from the gastrointestinal tract when taken with food; absorption is substantially reduced if fenofibrate is administered after an overnight fast. It is rapidly hydrolyzed to its active metabolite fenofibric acid which is extensively bound to plasma albumin. The plasma elimination half-life is about 20 hour. Fenofibric acid is excreted predominantly in the urine, mainly as the glucuronide conjugate, but also as a reduced form of fenofibric acid and its glucuronide.
