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Concomitant administration of salbutamol and other beta2 agonists, corticosteroids, diuretics or xanthines increases the risk of hypokalemia and monitoring of potassium concentrations is recommended in severe asthma, where such combination therapy is the rule.
Other short-acting sympathomimetic aerosol bronchodilators or epinephrine should not be used concomitantly with Salbutamol sulfate. If additional adrenergic drugs are to be administered by any route, they should be used with caution to avoid deleterious cardiovascular effects.
Beta-adrenergic blocking agents (e.g. acebutolol, atenolol, labetalol, metoprolol, nadolol, pindolol, propranolol, timolol) may prevent the adrenergic bronchodilators from working properly.
Disopyramide, quinidine, phenothiazines or procainamide may increase the risk of heart problems.
