Sign Out
Pharmacology: Pharmacodynamics: Mechanism of Action: Both in healthy persons and in patients with type 2 diabetes mellitus, glimepiride decreases blood glucose concentrations, mainly by stimulating insulin release from pancreatic beta cells.
Pharmacokinetics: Glimepiride is completely absorbed from the GIT. Peak plasma concentrations occur in 2-3 hours, and it is highly protein bound. The drug is extensively metabolized to two main metabolites, a hydroxy derivative and a carboxy derivative. The half-life after multiple doses is about 9 hrs. Approximately 60% of a dose is eliminated in the urine and 40% in the feces.
Continue with Google