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Should be used with care in pregnancy and during breast feeding, since the act on the renin-angiotensin system have been associated with fetal toxicity in humans.
Should be used with caution in patients with renal artery stenosis.
Reduced doses may be required in patients with renal impairment and hepatic impairment.
May experience hypotension in patients with volume depletion (e.g. patients who have received high-dose diuretic therapy) which may be minimized by initiating treatment with a low dose of Losartan Potassium.
Serum-potassium concentrations should be monitored, especially in the elderly and patients with renal impairment, and the concomitant use of potassium-sparing diuretics should generally be avoided since hyperkalemia may occur.
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