Arbloc Plus Special Precautions

Losartan Potassium and Hydrochlorothiazide: Renal and hepatic impairment; Pregnancy and breastfeeding.
Losartan Potassium: Patients with renal artery stenosis; may experience hypotension in patients with volume depletion (e.g. patients who have received high-dose diuretic therapy) which may be minimized by initiating treatment with a low dose of Losartan Potassium; serum-potassium concentrations should be monitored, especially in the elderly and patients with renal impairment, and the concomitant use of potassium-sparing diuretics should generally be avoided since hyperkalemia may occur.
Hydrochlorothiazide: Patients who are at risk from changes in fluid and electrolyte balance, such as the elderly; patients with hepatic cirrhosis are also more likely to develop hypokalaemia; hyperglycaemia and may exacerbate diabetes mellitus; may precipitate attacks of gout; systemic lupus erythematosus; may increase risk of developing gall stones.