Individualized dosage and may increase after at least 2 wk. Recommended dose: Telmisartan 20-80 mg once daily & amlodipine 2.5-10 mg once daily. Max: 80 mg/10 mg once daily.
Hepatic impairment. Discontinue immediately during pregnancy. Not recommended during lactation. Elderly >75 yr. Telmisartan: Symptomatic hypotension may occur in patients w/ an activated renin-angiotensin system eg, vol- or salt-depleted patients. Hyperkalemia may occur in patients w/ advanced renal impairment, heart failure, on renal replacement therapy, or on K supplements, K-sparing diuretics, K-containing salt substitutes or other drugs that increase K levels. Reduced clearance in patients w/ biliary obstructive disorders. Amlodipine: Symptomatic hypotension in patients w/ severe aortic stenosis.
Do not administer w/ aliskiren. Telmisartan: Reversible increase in serum conc & toxicity of lithium. Median increase in peak plasma conc & trough conc of digoxin. Amlodipine: Increased exposure to simvastatin.
C09DB04 - telmisartan and amlodipine ; Belongs to the class of angiotensin II receptor blockers (ARBs) and calcium channel blockers. Used in the treatment of cardiovascular disease.
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