Aprovel Dosage/Direction for Use

General: The usual initial dose of Aprovel is 150 mg once daily. Patients requiring further reduction in blood pressure should have the dose increased to 300 mg once daily.
If blood pressure is not adequately controlled with Aprovel alone, a diuretic (eg, hydrochlorothiazide 12.5 mg daily) or another antihypertensive drug (eg, beta-adrenergic blocking agent, long-acting calcium channel blocking agent) may be added.
In patients with hypertension and type 2 diabetic renal disease, 300 mg of Aprovel once daily is the preferred maintenance dose.
Aprovel may be administered with or without food.
Special Population: Pediatric Patients: Safety and effectiveness in pediatric patients have not been established.
Elderly patients: No dosage reduction is generally necessary in the elderly.
Among patients who received irbesartan in clinical studies, no overall differences in efficacy or safety were observed between older patients (65 years or older) and younger patients.
Hepatic impairment: No dosage reduction is generally necessary in patients with impaired hepatic function (mild to moderate degree).
Renal impairment: No dosage reduction is generally necessary in patients with impaired renal function (regardless of degree).
Patients with intravascular volume depletion: In severely volume-depleted and/or sodium-depleted patients, such as those treated vigorously with diuretics or hemodialysis, the condition should be corrected prior to administration of Aprovel, or a lower initial dose should be considered. If the blood pressure is not adequately controlled, the dose can be increased.