Anpheclor Dosage/Direction for Use

Doses are expressed in terms of Chloramphenicol base and are similar whether administered by mouth or intravenously. For adults and children, the usual dose is 50 mg per kg body weight daily in divided doses every 6 hours up to 100 mg per kg body-weight daily may be given in severe infections due to moderately resistant organisms, although these higher doses should be reduced as soon as possible. To minimized the risk of relapse, it has been recommended that treatment should be continued for 4 days after the patients' temperature has returned to normal in rickettsial diseases and for 8 to 10 days in typhoid fever. In cases of severe infection, premature and full term neonates may be given daily doses of 25 mg per kg body weight and full-terms infants over the age of 2 weeks may be given up to 50 mg per kg daily, in 4 divided doses. However, Chloramphenicol (Anpheclor) should only be used when there is no other suitable treatment for the severe infections and when concentrations can be monitored.
In patients with impaired hepatic function or severe renal failure, the dose of Chloramphenicol (Anpheclor) may need to be reduced because of decreased metabolism or excretion of Chloramphenicol (Anpheclor).