Amvasc Plus Contraindications

Hypersensitivity to amlodipine besilate, hydrochlorothiazide, other sulfonamide derivatives, or to any of the excipients of Amvasc Plus.
Advanced aortic stenosis because amlodipine can worsen the abnormal valve pressure gradient associated with this condition.
Severe hepatic impairment and/or cholestasis; anuria and renal impairment; gout and/or hyperuricemia.
Known history of cardiogenic shock.
Use in pregnancy: Pregnancy Category C. Amlodipine has been shown to be fetotoxic in laboratory animals. There are no adequate and well-controlled studies in pregnant women.
Thiazides must be avoided during the 1st trimester of pregnancy. Thiazides cross the placental barrier and appear in cord blood.
Amvasc Plus should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Use in lactation: Thiazides appear in human breast milk. It is not known whether amlodipine is excreted in breast milk. Clinicians should consider risk/benefit ratio for breastfeeding women.